Tesofensine works by increasing the levels of key neurotransmitters in the brain, helping to reduce hunger and enhance satiety.
Please read the following excerpts from studies available online
https://pubmed.ncbi.nlm.nih.gov/20385125/
Compared to baseline, long-term treatment with tesofensine resulted in a significant, dose-dependent and sustained weight loss of 5.7% and 9.9%,
https://pubmed.ncbi.nlm.nih.gov/19548858/
Results: After 26 weeks, tesofensine caused a significant weight loss, and may have a higher maximal ability to reduce weight than the presently available anti-obesity agents.
Conclusions: It is encouraging that tesofensine 0.5 mg may cause almost double the weight loss observed with sibutramine or rimonabant.